Abscisic acid ameliorates motor disabilities in 6-ohda-induced mice model of Parkinson's disease

Parkinson's disease (PD) is characterized by a myriad of symptoms, encompassing both motor disabilities and cognitive impairments. Recent research has shown that abscisic acid (ABA) phytohormone found in various brain regions several mammals exhibits neuroprotective properties. To investigate the effects ABA on disorders, mouse model PD was utilized. The administration 6-hydroxydopamine (6-OHDA) to lateral ventricles conducted, with (10 15 μg/mouse, i. c.v.) being administered for one week after 6-OHDA injection 4 days. Motor performance were evaluated through use open field, rotarod, wire grip, shuttle box tests. results indicated function disorders significantly impaired 6-OHDA-treated animals. However, mice treated 6-OHDA, (15 μg/mouse) reversed balance muscle strength deficits. It should be noted did not improve impairment or rearing Parkinsonism mice. Therefore, findings suggest plays crucial role protecting from caused 6-OHDA.